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By James Villepigue CSCS • May 2, 2019

Tadalafil (Cialis) – What You Thought You Knew – Benefits Well Beyond Erectile Dysfunction

Benefits-1Sometimes we can be so "hard" headed and think we know it all. Did you know there are so many amazing health benefits of Tadalifil (Cialis) like lessing the need to hit the head in the middle of the night, lowering blood pressure, increase blood flow for work outs and exercise, of course in the bed room, and so many more!

While plenty of research has focused on Tadalafil’s (Cialis) potent restoration of an erection, cutting-
edge research has recently shed light on other benefits way beyond erectile dysfunction! These powerful benefits have virtually gone unnoticed by the general public.

This article will discuss 2 of these benefits in domains which are extremely relevant to older men who suffer from erectile dysfunction – Prostatic Hyperplasia and Cancer.

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Tadalafil and The Prostate
It comes as no surprise that Tadalafil is the superior and more effective drug than Sildenafil (Viagra) for erectile dysfunction. However, Tadalafil has other benefits that extend beyond erectile dysfunction. A review conducted in 2014 which critically analysed 125 studies, showed that Tadalafil represents a new paradigm in the treatment of benign prostatic hyperplasia (BPH) – a disease characterized by abnormal growth of the prostate gland in older men. In fact, Tadalafil is the only known drug available that can treat erectile dysfunction and BPH concomitantly.

WellTadalafil and Cancer
Tadalafil was shown to have antitumor activity in a study published in 2017 – patients with advanced melanoma (a form of skin cancer which is prevalent in the United States), enjoyed better clinical outcomes when they were administered oral Tadalafil. Furthermore, the researchers concluded that Tadalafil is safe in patients with metastatic (advanced) melanoma – only 8% of patients reported nausea and 4% reported headaches [2].

Supporting these findings were results published by researchers studying head and neck cancer in 2015. A randomized, double-blind, placebo-controlled clinical trial, which represents the highest level of evidence, showed that the immune function in patients with squamous cell carcinoma of the head and neck was augmented with Tadalafil. In other words, the immunity suppressing activity of this specific cancer was reversed with Tadalafil – representing a new advance in cancer immunotherapy [3].


  1. Huang, S.A. and J.D. Lie, Phosphodiesterase-5 (PDE5) Inhibitors In the Management of Erectile Dysfunction.P & T : a peer-reviewed journal for formulary management, 2013. 38(7): p. 407-419.
  2. Hassel, J.C., et al., Tadalafil has biologic activity in human melanoma. Results of a pilot trial with Tadalafil in patients with metastatic Melanoma (TaMe).Oncoimmunology, 2017. 6(9): p. e1326440-e1326440.
  3. Califano, J.A., et al., Tadalafil augments tumor specific immunity in patients with head and neck squamous cell carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research, 2015. 21(1): p. 30-38.